You can manually remove individual mailboxes from Exchange Online backup content using the Exclude Content tool. When you exclude a mailbox, backup jobs no longer run on that mailbox.
For users who have been manually excluded from a backup, the discovery type becomes manual. These users do not consume an application user license.
Important
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For excluded users with manual discovery type and are Active in Azure:
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The back-end sync process will continue to scan such mailboxes and mark the deleted emails as soft deleted.
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All active emails remain in the Active state and will be counted against the existing capacity.
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For excluded users with manual discovery type and are Deleted in Azure:
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The back-end sync process will attempt and fail to scan such mailboxes as the mailbox will be deleted from Azure as well.
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All emails from such mailboxes which were in the Active state when the mailbox was deleted will continue to remain active and will be counted against the existing capacity.
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Procedure
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From the navigation pane, go to Protect > Office 365.
The Office 365 Overview page appears.
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On the Apps tab, click the app.
The Overview page of the app appears.
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On the Content tab, in the upper-right area of the page click Add.
The Configure Content page appears.
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Select Exclude content from backup, and then click Next.
The Exclude Content tool appears.
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Under Standard, select Mailboxes, and then click Next.
The Content tab appears.
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In the list, select the mailboxes that you want to exclude from backups, and then click Next.
The Summary tab appears.
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Click Submit.